Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. 25mg of quetiapine is a low dose. In the elderly population we usually start with 25mg twice daily and we may proceed with rapid increases (as many as 50mg per day) depending on the patient s response (and lack of side effects like drowsiness, instability, etc). 25mg sounds like a trial to me, to see how he would respond to the drug. If his outbursts are too hard to control then perhaps your doctor should raise the dosage. If they re not frequent your doctor may suggest a prn dose (pro re nata - when needed) to calm him down. I ve used your doctor many times to emphasize the fact that your doctor is the most appropriate person to take such decisions. Your can help him/her by providing useful information about your father s functional status. For example: - does he sleep at night? - is he aggressive and may harm others or himself? - does he eat normally? Has the drug affected his eating? - can he walk and is he stable enough after taking the drug? - is his blood pressure under control (sometimes even low doses may cause hypotension) - are there any other side effects you ve noticed? So in conclusion, the answer to your question is that this is very low (initial) dose and your doctor may go to much higher doses if necessary. You can help him take that decision by providing information about your father s functional status. Hope I have answered your query. Let me know if I can assist you further.