I have been taking Nadolol for over 10 years for high blood pressure. My hands, fingers, legs & feet stay cold all the time. In the last six months this condition has gotten much worse. Everyday around 5:00p my fingers turn white, get numb and very cold. I then cannot pick up anything, cannot feel my computer keys, and do everything I can to warm my fingers. The only thing that helps is running hot water on my fingers for about 3-5 minutes, and then my fingers turn red, the cold seems to go away and I can pick up papers, feel my computer keys -- this may last for 30-45 minutes and the cold & numbness re-appears. My ankles swell out over my shoes and my legs below the knew also swell. I have gained 50 pounds over the last six months. I had no clue as to what might be causing these problems until yesterday my Rheumatologist review my RX list and said Nadolol can cause all these conditions, and suggested a lab test to rule out lupus & Raynard s -- I took the blood test but don t have the results yet. He also suggested talking to my cardiologist. Do you have any advise. 10/06/16 Richard H.