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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Does A Negative Blood Work But A Positive Biopsy Indicate?

Hello, I had a biopsy 9 months ago and it was positive for subacute cutaneous lupus. But my blood work is normal. I have a rash on my face, chest arms , inner thighs and calves . The rash does not go away and they turn purple in cold or hot water. I have severe pain in my hands , knees, lower back and elbows. My muscles hurt very bad and they are weak. I wake up with migraines for up to 7 days straight. My question is why is my blood work neg. but my biopsy psitive and i experience all these symptoms and can S.C.L.E. turn into S.L.E?
Mon, 1 Sep 2014
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Rheumatologist 's  Response
Good evening. Subcutaneous lupus is a benign condition. It normally limits itself to the skin and may cause joint pains occasionally. You blood work is negative cause it may not be involving any of your organs. Which is a good thing.

For SCLE to turn into SLE, one needs to have ANA positive or some other antibodies in ENA profile. I am not too sure if you have those results.

Also supplement your self with vitamin D treatment, as lupus patients are to avoid exposure to sun.Vitamin D Deficiency can cause the arthalgias which you are experiencing. . Hope the information was useful
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What Does A Negative Blood Work But A Positive Biopsy Indicate?

Good evening. Subcutaneous lupus is a benign condition. It normally limits itself to the skin and may cause joint pains occasionally. You blood work is negative cause it may not be involving any of your organs. Which is a good thing. For SCLE to turn into SLE, one needs to have ANA positive or some other antibodies in ENA profile. I am not too sure if you have those results. Also supplement your self with vitamin D treatment, as lupus patients are to avoid exposure to sun.Vitamin D Deficiency can cause the arthalgias which you are experiencing. . Hope the information was useful