I am 52 years old, and my doctor has prescribed 100mg of Prometrium and 1 mg of Estradiol every night before bed to help combat the following symptoms: mood fluctuation, anxiety, muscle and joint pain, difficulty sleeping, bloating and weight gain and hot flashes. I am concerned about the possible side effects. I have a very busy job, and cannot afford to feel unwell. What can I expect to feel, if I take these medications together. thanks. Maria