Hi, I hope you are well, you must know that the liver disease associated with iron overload is called hemochromatosis. This disease usually has a hereditary origin, is rare, and its diagnosis is made by an iron panel; must have a transferrin saturation 45% and/or a ferritin level 150 in men and 200 in women, since these determinations can be altered in the presence of any hepatic involvement, alcohol consumption, infectious process, etc. If these analytical alterations were present, the next step would be the investigation of the genetic alterations in the HFE gene whose alteration is the C282Y mutation. It mainly presents an involvement of the liver, pancreas, heart, pituitary. The main abnormalities that are to be found are alterations in hepatic chemistry, weakness, fatigue, diabetes mellitus, cutaneous hyperpigmentation, arthralgia, impotence, cardiac abnormalities. There is a triad characterized by hepatic cirrhosis, diabetes mellitus and cutaneous hyperpigmentation that usually occurs but in late stages of the disease. There are measures to control the disease and prevent the progression of multiorgan damage, which is why an early diagnosis should be made.