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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Vomiting And Nausea After Taking Martifur For UTI?

My wife is suffering from urinary infection, her pus cells being 15-18. She has been prescribed martifur 100 mg twice daily for one week and thereafter once daily for one month. After taking the first dose she felt nausea and vomitted twice. She is 73 year old. Her urine test for culture and sensitivity Shows no growth. Should she continue with martifur or discontinue it and start some other medicine. Please advise.
Tue, 29 Mar 2016
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Internal Medicine Specialist 's  Response
Thanks for asking at Healthcare Magic. I read your question and I understand your concern.
Martifur (nitrofurantoin) is notorious for nausea and vomiting.
Only pus cells in urine with no symptoms of UTI like burning micturation, fever etc. is not significant. Urine C/S report with no growth of bacteria has negative predictive value only if culture has been taken prior to use of antibiotics.
If your mother has symptoms of UTI and pus cells or culture was taken after antibiotics then she has to continue medications.
I would like to advise you to start him on prokinetic
to relieve nausea. if she can't tolerate despite of prokinetic then change her antibiotic to fosfomycin that has good spectrum against gram negative bacteria that are the culprit in UTI.
Take plenty of water, cranberry juice and garlic.
Hope it helps best.
Don't forget to rate this answer and close the discussion at Healthcare Magic.
Take your best care and of your mother.
Regards
Dr Ejaz
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What Causes Vomiting And Nausea After Taking Martifur For UTI?

Thanks for asking at Healthcare Magic. I read your question and I understand your concern. Martifur (nitrofurantoin) is notorious for nausea and vomiting. Only pus cells in urine with no symptoms of UTI like burning micturation, fever etc. is not significant. Urine C/S report with no growth of bacteria has negative predictive value only if culture has been taken prior to use of antibiotics. If your mother has symptoms of UTI and pus cells or culture was taken after antibiotics then she has to continue medications. I would like to advise you to start him on prokinetic to relieve nausea. if she can t tolerate despite of prokinetic then change her antibiotic to fosfomycin that has good spectrum against gram negative bacteria that are the culprit in UTI. Take plenty of water, cranberry juice and garlic. Hope it helps best. Don t forget to rate this answer and close the discussion at Healthcare Magic. Take your best care and of your mother. Regards Dr Ejaz