Hello dear, Understand your concern Following are side effects of depot shot: 1. Doesn’t protect against STIs 2.Wweight gain, tiredness, and possibly a decrease in bone density 3.very irregular menstrual bleeding or spotting. So i think it is withdraw effect of it. Yeast infection most common due to candidiasis. Take the following advice for it 1. Single dose oral Diflucam, if not respon you can take three dose 2. Ointment trazol 3. Probiotic tablet orally/vaginally 4. Take yougort and balanced healthy diet 5. Boric acid suppository 6. Maintain hygiene 7. Wash your vagina with warm salt water 4-5 times in a day 8. Wear loose pure cotton inner wear 9.Keep the vagina clean (Not wet) Hope this may help you Wish you good health Best regards Dr. Sagar