Hi.. Welcome to HEALTHCARE MAGIC.. I have gone through your query and can understand your concerns.. As per your complain hives on lips, fingers and toes along with Angioedema of lips with severe itching seems to be most probably due to allergic reaction that can be due to any food or medicine, allergic reaction to leather, later, skin cosmetics etc.. I would suggest you to consult an Allergist and get evaluated and a thorough clinical evaluation and investigations like allergic tests like Patch test, RAST test, food challenge test etc can help in diagnosis and treatment can be done accordingly.. The tests will help in ruling out the exact cause of the allergen and once you know the cause of the allergic reaction you can avoid exposure to it to prevent allergy attack.. The allergist can advise to oral anti allergics as well as injectable steroids for relief.. As of now you can take anti-allergics like Levocetrizine, Allegra to control the itching and swelling.. Do cool compresses.. Application of calamine lotion can help in soothing the skin.. You can also be instilled an Immunotherapy that will help in reducing the severity and frequency of allergic attack.. Hope this information helps.. Thanks and regards.. Dr.Honey Nandwani Arora..