Hello, Depo Provera is a progesterone hormonal pill. Once you finished the course automatically body will eliminate the drug within a few weeks. The main cause of your weight can be not only this medication but the condition a polycystic ovarian disease. Hence I suggest you take simple steps initially 1. Excercise-like walking/swimming 2. Change diet habits include more salads, green vegetables, take supplements like multivitamins, multivitamins, omega 3 fatty acid supplements. Proper hydration, antioxidants like vitamin E and vitamin C capsules. 3. Kindly check your thyroid status. All the above steps will decrease the intensity of polycystic ovarian diseases as such which leads to hormonal balance and thus balance your weight initially, later even reduces. These are main yet easy measures to be taken. If you persist with it detoxifies and t 70 to 80 per cent problem is solved. Other options include using other hormonal pills after consulting the present status with gynaecologist, as these medications need to prescribed after examination to make sure no under or overdosing occurs. Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr Anusha Molugu, Anesthesiologist