Hello dear I understand your concern Your symptoms could be related to inflammatory bowel disease or cealiac disease, infection of the gastrointestinal tract as colonoscopy is normal. Take following advises: I advice to to consult the Gastroenterologist for better evaluation and undergo following investigation: Stool microscopy and culture Blood tests: Full blood examination, LFT, ESR, and serological testing for coeliac disease Abdominal ultrasound, endoscopy to rule out the ulcer and colonoscopy. Hydrogen breath testing to rule out malabsorption. Doctor will give following advises: Take solubel fiber like ispagula husk. if not responds then laxative like sorbitol and lactulose will help Avoid spicy diet , take small frequent meal rather than large meal. Anti diarrheal: loperamide. SSRIs and atypical anti psychotic:fluoxentine, clozapine. anti spasmodic like mebeverine and dicyclomine Sporolac sachet Take food like boiled rice, applesauce, banana, toast, yogurt and curd Avoid stress and do regular exercise like walking and yoga. Hope this may help you Contact HCM for further health query Best regards Dr. Sagar