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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Severe Fatigue While On Seroquel XR?

I m on seroquel XR 300mg. I was at a dosage of 600 mg. For one to two years experimenting what is causing my extreme fatigue and weakness. I did not notice a difference when dropped to 300 mg. I think we dropped to 150mg but my doctor quickly upend it to 300mg. My doctor does not want me to get off serequel XR because I could end up in the psyc ward again. I was working 12 hours a week at work then dropped it to 8 hours a week. Still feel the same if I worked but only tried this out once but continue to work 8 hours a week. I work 4 hour shift as a grocery cashier. To get to the point..... I m so tired of experimenting with drugs and drugs highly affect me. Stopped experiencing drugs when I got a major allergic reaction to a drug. I was wondering if get off serequel XR 300mg one per night if there is a better medicine that boosts energy instead of knocking me out daily? I would be happy to give more info but I guess asking if off serequel what is a good substitute to help with my energy and mood stabilizer. Thank you gorgeous your time. Micah
Mon, 25 Sep 2017
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General & Family Physician 's  Response
Hello,
Thank you for trusting HealthcareMagic for your health concern

Seroquel can cause fatigue and tiredness, mainly due to its anticholinergic action. Dose reduction can be tried. However, if dose reduction cause relapse ofpsychotic symptoms, then switching to another antipsychotic with lesser anticholinergic effecta like Risperidone can be tried. Please be advised to follow up with your psychiatrist to either reduce the dose of seroquel or switch to risperidone.

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Regards
Dr.Lekshmi
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What Causes Severe Fatigue While On Seroquel XR?

Hello, Thank you for trusting HealthcareMagic for your health concern Seroquel can cause fatigue and tiredness, mainly due to its anticholinergic action. Dose reduction can be tried. However, if dose reduction cause relapse ofpsychotic symptoms, then switching to another antipsychotic with lesser anticholinergic effecta like Risperidone can be tried. Please be advised to follow up with your psychiatrist to either reduce the dose of seroquel or switch to risperidone. Hope this answers your questions Please address further questions here Regards Dr.Lekshmi