Hi.. Thanks for the query.. Getting Canker sores on lower inner lip in about every 6 months is not abnormal and does not seems to be treated to Humira as an individual can get Canker sores 3 to 4 times in an year.. There are a number of causes like Stress, Nutritional Deficiency [Iron, Vitamin B12 and Folic acid] , hormonal changes, acid reflux, tongue trauma due to some sharp teeth or tongue biting habit, excessive intake of sour and citrus foods, uncontrolled diabetes and other immunocompromised conditions etc. For apthous ulcer you can do warm saline gargles Gargles with 1:1 solution of benadryl and milk of magnesia can help.. Apply numbing gel over the sore for relief from pain especially during eating.. Take Vitamin B complex supplements. Avoid spicy, sour and acidic foods.. In case if still the condition does not subside the physician can prescribe you to take a Steroid course can be advised. Hope this helps.. Regards..