Hi. The persistent pain in abdomen in spite of gall bladder removal may be due to following reasons: IBS as has already been suspected / Tuberculosis / diverticulitis / vascular problems of the intestines / intestinal obstruction and so on. I would advise you the following: I would have liked to see the medicines you have taken in past with dosage and investigations you have undergone. This is the most important. For us to say this as a IBS i.e. Irritable Bowel Syndrome, all the investigations should be normal. I would advise the following investigations and treatment in a such a case: Investigations: *Routine blood investigations like Complete blood picture, blood sugar, urea, creatinine, liver function tests, thyroid function tests. *Urine -routine and microscopy *Stool: routine, microscopy, occult blood, culture and sensitivity. *Ultrasonography of abdomen, *Colonoscopy All these investigations should be within normal limits for one to say you have IBS. If a specific cause is found out , it is easy to treat the problem.