you need to know angiooedema is rapid swelling of the dermis, subcutaneous tissue. mucosa and submucosal tissue. and it is similar to urticaria, but with urticaria, commonly s in the upper dermis hives, occurs in upper dermis. in your case if its only pain at ankle and knee level and there is no swelling involved then it may not be related to angioodema. i suggest to go ahead and have secondary opinion if there is any severe side effect with this.many times it is reported people who was taking this medication they have develop angioodema. so my question is for what your doctor have given you methotraxate and folic acid medication? well here its not clear in what you have mention so i strongly recommend to check with one more doctor on this with showing him all reports. here with out checking the detail report and the treatment history i can not suggest you on this so just giving general guideline. you can use cold pack and hot pack to reduce inflammation and swelling along with pain. you can also also take physiotherapy treatment to have some more relief and do knee and ankle exercise to increase the soft tissue strength with that also you will feel better. hope this was useful for you if there is any doubt right it here again with details. take care