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Dr. Andrew Rynne
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Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Nausea And Vomiting After Taking Simponi Injection?

Severe nausea 3-4 hr after simponi injection. Continuous throwing up lasting on and off for about 8hrs. I have been taking the injection for 10 months, but have only been getting sick for the last three injections. I can t take gravol. Restless leg syndrome from gravel. What to do?
Fri, 11 May 2018
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General & Family Physician 's  Response
Hello and Welcome to ‘Ask A Doctor’ service.
I have reviewed your query and here is my advice.

Simponi (golimumab injection) is a human IgG1k monoclonal antibody used to treat rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. Simponi is sometimes used with another medication called methotrexate (Rheumatrex, Trexall). Simponi works by blocking a protein (tumor necrosis factor or TNF) found in the body's immune system that causes joint swelling and damage.

Common side effects of Simponi include dizziness, cold symptoms (stuffy nose, sneezing, sore throat), or injection site reactions (redness, itching, pain, or swelling).

According to your history as described in your question there are symptoms of liver damage (including dark urine, persistent nausea/vomiting/loss of appetite, stomach/abdominal pain, or yellow eyes or skin).

Hope I have answered your query. Let me know if I can assist you further.

Regards,      
Dr. Narender Kumar
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What Causes Nausea And Vomiting After Taking Simponi Injection?

Hello and Welcome to ‘Ask A Doctor’ service. I have reviewed your query and here is my advice. Simponi (golimumab injection) is a human IgG1k monoclonal antibody used to treat rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. Simponi is sometimes used with another medication called methotrexate (Rheumatrex, Trexall). Simponi works by blocking a protein (tumor necrosis factor or TNF) found in the body s immune system that causes joint swelling and damage. Common side effects of Simponi include dizziness, cold symptoms (stuffy nose, sneezing, sore throat), or injection site reactions (redness, itching, pain, or swelling). According to your history as described in your question there are symptoms of liver damage (including dark urine, persistent nausea/vomiting/loss of appetite, stomach/abdominal pain, or yellow eyes or skin). Hope I have answered your query. Let me know if I can assist you further. Regards, Dr. Narender Kumar