Hello dear Understand your concern I think it is side effects of drug that cause hormonal imbalance. Meprate contain hormonal product. Following are common side effects: headaches, nausea, irregular bleeding, fluid retention, dizziness, weight gain and depressed mood, either sleepiness or insomnia, bloating, a decreased or increased sex drive, discomfort of the breasts. Also note that Menstruation required co ordinate action of various hormone that secreted by ovary (estrogen and progesterone) and brain (FSH and LH). If any above hormone is decreased or increased there is imbalance in menstruation. So please do full hormonal profile : Estrogen, progestron, LH, FSH, HCG and thyroid hormone. That help to diagnose hormonal imbalance. Also do Follicle study, endometrial biopsy and hysteroscopy. Take more frequent meal rather than large meal Relaxation exercise and musical therapy Do regular walking and exercise. Eat healthy diet Avoid excessive tea and caffeine Hope this may help you. Best regards Dr. Sagar