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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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What Causes Hepatic Cirrhosis And Hepatocellular Disease?

Im a 37 year old male. I drank heavily for about 5+ years. about 2 years ago I have a severe kidney ifection and let it go, this caused me to have full renal shutdown and like an idiot while this was happening I continued to drink to the point I turned jaundice. I was hospitalized for 2 months and recovered fully with no dialysis needed. A year ago I had a cholecystectomy, a few days later I was readmitted with pneumonia, left side pneumothorax, and MRSA. I recovered from that as well. I have continued to have severe right side abdominal pain right where the liver is. My GI Dr had me go for an MRI with contrast. Results are There is evidence of contour nodularity of the liver consistent with hepatic cirrosis and hepatocellular disease. I have been sober over a year. What does this mean?
Full info from the MRI Results as I could not fit it into the original question:
There is evidence of contour nodularity of the liver consistent with hepatic cirrosis and hepatocellular disease. The liver demonstrates heterogeneous enhancement with somewhat irregular lacy areas of enhancement scattered throughout the liver and the noduals may indicate some areas of regeneration (which that part is good). There is one area in the right lobe of the liver lateralally which demonstrates a wedge shaped area of greater enhancement but not have the appearance of a mass. The spleen is also enlarged and a ct/pets scan should be reformed for further evaluation. Over all impression is evidence for hepatosplenomegaly. Contour nodularity of the liver and heterogeneous enhancements felt secondary to hepatocellular disease the wedge shaped area although not believed to be a mass could be representative of some sort of transient vascular phenomenon rather then a mass. There is also evidence of perihepatic ascities.
Thu, 22 Sep 2016
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General Surgeon 's  Response
Hello,
1) Your diagnosis is Alcohol related liver cirrhosis with portal hypertension
2) Alcohol damages liver by affecting work capacity of cells in liver. This damaged cells can not regenerate to produce more cells and as a result of that damaged liver cells are replaced by fibrous tissue. (Process is similar to healing of any deep wound on skin which would not be same skin)
3) Because of damage to liver tissue and decreased ability to reproduce new liver cells, liver function gets deteriorated gradually (Once liver damage, this deterioration is irreversible)
4) Because of these changes, not only liver function is affected but vessels which supply blood to liver (Portal vein) are also affected and develop high pressure within this vein which causes portal hypertension (causes enlargement of spleen). In severe cases portal hypertension may cause blood vomiting. To prevent this periodic upper GI endoscopy is necessary.
5) To evaluate condition periodically, USG abdomen for status of liver is mandatory
6) To support liver function, you may require medical gastroenterologist consultation and supportive treatment over long period of time with abstinence from alcohol
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What Causes Hepatic Cirrhosis And Hepatocellular Disease?

Hello, 1) Your diagnosis is Alcohol related liver cirrhosis with portal hypertension 2) Alcohol damages liver by affecting work capacity of cells in liver. This damaged cells can not regenerate to produce more cells and as a result of that damaged liver cells are replaced by fibrous tissue. (Process is similar to healing of any deep wound on skin which would not be same skin) 3) Because of damage to liver tissue and decreased ability to reproduce new liver cells, liver function gets deteriorated gradually (Once liver damage, this deterioration is irreversible) 4) Because of these changes, not only liver function is affected but vessels which supply blood to liver (Portal vein) are also affected and develop high pressure within this vein which causes portal hypertension (causes enlargement of spleen). In severe cases portal hypertension may cause blood vomiting. To prevent this periodic upper GI endoscopy is necessary. 5) To evaluate condition periodically, USG abdomen for status of liver is mandatory 6) To support liver function, you may require medical gastroenterologist consultation and supportive treatment over long period of time with abstinence from alcohol