Hello, * As per my clinical experience, there are ample number of conditions which can present as gradual weight loss with erectile dysfunction as - metabolic derangements (diabetes or else) - hypothalamus or pituitary disorders - problems with testosterone or other hormones - hematological issues as low counts - hidden inflammation process, malignancy or else * In my clinic, I recommend a complete set up of hormone workup for the best possible cause evaluation and management. However, providing previous work up details would be best at this point to discuss further. Hope I have answered your query. Let me know if I can assist you further. Take care Regards, Dr Bhagyesh V. Patel, General Surgeon