My husband has CTCL,was in remission with campath, came out of remission last fall, and in the winter had both ECP and interferon, what did not have good results. His lymphocytes have been increasing and his itching syndrome continues. HE is in Post Day 2 of his second week having romidepsin. He is nauseous and fatigued, tho hasn t thrown up, but has had had a couple of nosebleeds and has had blood in his stools, bright fresh blood...twice, once after the first dose and again today. Should I call the Dr.? also, does this get cumulatively worse?