Hi Thanks for choosing HCM for your query. Incomplete data: Age, gender, purpose of taking Omeprazole, any co existing disease or medication intake not mentioned. I really appreciate your concern towards the safety of Omeprazole on long term use. Well, the short term use of Omeprazole or other related PPIs have totally revolutionized the acidity relate stomach or food pipe problems like GERD, or peptic ulcer. There is a concern regarding its safety. On long term use these drugs are known to cause thinning of the bones to the extent of causing fractures (especially around the hip joint), increased risk of getting intestinal infections (lack of acid means no barrier to the invading harmful germs), deficiency of vitamin B12 resulting in anemia and neurological problems, etc. The bone and the neurological effects can be prevented with the use of Vitamin D with Calcium and dietary supplement of Vitamin B12. Life style modifications are definitely the mainstay in the management of acidity related problems. Avoidance of stress, hot and spicy foods, alcohol, smoking, chocolates, etc. The time interval between having the last meal of the day (dinner) and going to be should be atleast 3-4 hours, can be effective. Hope these suggestions are helpful in your case. Kindly give your valuable feedback.