Dr. Hanif warmly welcomes you! Thanks for consulting at my virtual clinic HCM. I have carefully worked through your case, and can well realize your health worries. Being your physician, I want to assure, I will take care all of your medical concerns. Enbrel doesn t cause directly any side effects like arthritis. This knee pain may be due to some other reason. Some drugs also cause joint issues like this but Etanercept (Enbrel) isn t one of them. It may be due to autoimmune disease, increased levels of uric acid, increased wear and tear of the joint that happens in obese people. Consult an Orthopedist for proper in-person evaluation and treatment goes accordingly. He will help you for that. For temporarily pain may be relieved by applying Bengay Ultrastretch Gel on the knee and massage very gently. Then apply a knee cap for relief. Take Excedrin Extra Strength for pain relief. Take plenty of water and avoid physical activity to reduce inflammation. Rest be assured, you will get better soon. Hope I answered all of your questions. Please click on I Find This Answer Helpful and don t forget to add your precious positive feedback to help me able to assist you better in future too. Have a wonderful time ahead. Keep in touch for a follow-up too to let me know if you have any doubts & need further assistance. I am available 24/7 for providing you my expert medical opinion on any issue. Have a blessed time ahead. Regards! DR. MUHAMMAD HANIF USA