Hi. Statins like Crestor (Rosuvastatin) are the most effective oral medications for lowering your cholesterol, The most common side effects of statins include myopathy (muscle pain, tenderness, or weakness), liver dysfunction, stomach upset, confusion, memory problems and dark colored urine. However, one particular statin may cause side effects for while another stain won t. It s thought that simvastatin (Zocor) may be more likely to cause muscle pain as a side effect than other statins when it s taken at high doses. Further,the risk of myopathy and other side effects can be minimized by taking Crestor every other day. Hope these answer your query.