Hello; Weed or Marijuana cigarette or Cannabis is often consumed for its mental and physical effects, such as heightened mood, relaxation, and an increase in appetite. Possible side-effects include a decrease in short-term memory, dry mouth, impaired motor skills, red eyes, and feelings of paranoia or anxiety. Onset of effects is within minutes when smoked and about 30 minutes when eaten. They last for between two and six hours. MDMA ( contracted from 3,4-methylenedioxy-methamphetamine ) is a psychoactive drug of the substituted methylenedioxyphenethylamine and substituted amphetamine classes of drugs that is consumed primarily for its euphoric and empathogenic effects. As the above descriptions, these two material have opposite effect in the mind and serum plasma. Thus, consuming and overdose taking of these material put two opposite effects on the body and its blood. These effects, as noted before, are transient; but you must be try to take away both of them; for all. If still there is / are a problem/problems that it/they worry and anxious you, please do not hesitate for telling to me. Thanks!