Hi, Thanks for posting in HCM. I understand your concern. Enbrel contains etanercept which works by decreasing a certain protein produced by the immune system. Etanercept is a biopharmaceutical that treats autoimmune diseases by interfering with tumor necrosis factor by acting as a TNF inhibitor. Hence, it is used to treat the symptoms of rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis, and to prevent joint damage caused by these conditions. The major side effects of its use include: 1. increased risk of developing certain types of cancer 2. serious and sometimes fatal infections can occur due to weak immune system. Kindly get evaluated clinically before you start the treatment with this medication. If it is going to be more beneficial and effective to treat your underlying condition, kindly go ahead and do not worry about the side effects as you can take certain amount of precautions to avoid them. Hope the information provided would be helpful. All the best.