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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Suggest Treatment For Increased SGOT And SGPT Level Along With Fatty Liver

I am 53 yrs male non-alcoholic. Height 164 cm & weight 84 kg. Total cholestrol 5.1 mmol/l with zocor medication. Recently my blood chemistry (liver function test) revealed that my SGOT/AST & SGPT/ALT readings of 132v & 232v respectively. My doctor explained that I am having fatty liver. He then prescibed me to take Livolin Forte capsules twice (morning & at night) daily. Can doctor explain to me more about the readings of my liver function test (SGOT/AST & SGPT/ALT) whether very alarming or not? What are the side effects of consuming Livolin Forte in the short & long term? Thank you. Hamzah Nassir.
Tue, 2 May 2017
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General & Family Physician 's  Response
Hi i hope you are very well The alteration that you present in your liver chemistry according to ALT levels is a moderate elevation, with a hepatocellular pattern. Your diagnosis may actually be a fatty liver, however, this is a very broad spectrum that includes hepatic steatosis and steatohepatitis.

You have metabolic risk factors for fatty liver such as your overweight / obesity and dyslipidemia. You should have a checkup for suspected diabetes mellitus and systemic arterial hypertension.

There are several non-invasive studies to evaluate the degree of fibrosis or even cirrhosis, the one with the highest diagnostic yield is the transient elastography (Fibrotest), however, to differentiate between steatosis and steatosis hepatic biopsy should be performed. The importance of detecting a steatohepatitis is for prognostic purposes, since the progression to cirrhosis is greater.

The treatment indicated in these cases is mainly non-pharmacological, the loss of weight is fundamental as well as a modification in the lifestyle, a balanced diet, increase in the physical activity. An approximate loss of 5-10% of weight is suggested in a period of 6 to 12 months, this is associated with an analytical and histological improvement.

There are very few drugs that can be useful. One of them is Vitamin E in doses of 400,000 to 800,000 U / day especially in people who do not have diabetes mellitus. Other medications currently being used are statins like simvastatin that you consume, as it has antifibrotic properties.
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Suggest Treatment For Increased SGOT And SGPT Level Along With Fatty Liver

Hi i hope you are very well The alteration that you present in your liver chemistry according to ALT levels is a moderate elevation, with a hepatocellular pattern. Your diagnosis may actually be a fatty liver, however, this is a very broad spectrum that includes hepatic steatosis and steatohepatitis. You have metabolic risk factors for fatty liver such as your overweight / obesity and dyslipidemia. You should have a checkup for suspected diabetes mellitus and systemic arterial hypertension. There are several non-invasive studies to evaluate the degree of fibrosis or even cirrhosis, the one with the highest diagnostic yield is the transient elastography (Fibrotest), however, to differentiate between steatosis and steatosis hepatic biopsy should be performed. The importance of detecting a steatohepatitis is for prognostic purposes, since the progression to cirrhosis is greater. The treatment indicated in these cases is mainly non-pharmacological, the loss of weight is fundamental as well as a modification in the lifestyle, a balanced diet, increase in the physical activity. An approximate loss of 5-10% of weight is suggested in a period of 6 to 12 months, this is associated with an analytical and histological improvement. There are very few drugs that can be useful. One of them is Vitamin E in doses of 400,000 to 800,000 U / day especially in people who do not have diabetes mellitus. Other medications currently being used are statins like simvastatin that you consume, as it has antifibrotic properties.