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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Suggest Treatment For Elevated ALT And AST Levels

45 year old male with elevated alt 144 / ast 58. These numbers have been going up since 2012. I had been taken Lipitor for over 12 years and Dr. Changed my Med to Zentia after discovered elevation of alt/ast. I recently was diagnosed with Hyperthroidism and T3 andT4 and TSH numbers were all out of wack. Question, will Thyroid problem make Cholesterol / Liver Enzymes# s be out of wack or did the long term use of Lipotor elevate? I ve been on Zentia for better of 6 months now and Cholesterol numbers are coming down a little but Liver count is not also had a ultrasound done of liver and Suggestion was Fatty Liver Elevated LFT s. I do drink beer and wine but nothing harder that that and not that often. What advise do you have? I m scheduled to see my family doctor in a week.
Wed, 17 Jun 2015
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Gastroenterologist 's  Response
Well, both of the above-mentionned drugs can cause liver transaminases elevation, Lipitor as a statin being "more accused" of this side effect. Anywhere even Zetia could be interrupted for a month remaining only in a low fat diet, because it's not a "sine qua non" medicine for you, and then repeating another time the AST and ALT. I don't know about your virological tests if you have excluded hepatitis causes (B,C,D, E) of your abnormal LFT-s. Even autoimmune causes are to be excluded and drinking should be stopped before blaming liver steatosis for your high transaminases level. So a long way away, but be patient because there's nothing of an urgent situation.
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Suggest Treatment For Elevated ALT And AST Levels

Well, both of the above-mentionned drugs can cause liver transaminases elevation, Lipitor as a statin being more accused of this side effect. Anywhere even Zetia could be interrupted for a month remaining only in a low fat diet, because it s not a sine qua non medicine for you, and then repeating another time the AST and ALT. I don t know about your virological tests if you have excluded hepatitis causes (B,C,D, E) of your abnormal LFT-s. Even autoimmune causes are to be excluded and drinking should be stopped before blaming liver steatosis for your high transaminases level. So a long way away, but be patient because there s nothing of an urgent situation.