HI, thanks for using healthcare magic It is definitely possible that the swelling is related to the hydrocodone though systemically taken meds (eg not topical to nose, eyes, skin etc) normally cause a more wide spread reaction because they are in the blood stream. A localized reaction is more likely with something applied directly to a particular area. Unfortunately there is little to be done to cause the hydrocodone to break down or be excreted faster but you can take antihistamines to help with the allergic reaction. These would be over the counter medications such as benadryl, claritine, allegra or zyrtec One of these should reduce the swelling. I hope this helps