Hi, I was diagnosed with major depressive disorder 21 years ago. Only in about the last 4-5 years have I felt somewhat normal, until recently that is. About the last 6 months I've had a whole new set of symptoms. I am very easily irritated and when I do get irritated I get very mean, angry, upset, tearful and i just want to scream at everybody. At work I just want to be left alone to do my work and if I get any interruption from another employee I EXPLODE! I don't know what this is and I don't know how to control it and I don't know what to do. Can you please give me some idea as to what might be causing all this? Thank you, Mary Jo