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Suggest Treatment For Alport's Syndrome
Dear Sir, I like to know whether there is any treatment of disease "ALPORT'S SYNDROM" which is Kidney related. My grandchild 5.5 years old (Female) having problem of passing +2 proteins and plenty microscopic red blood cell with urine and it is detected that it is genetic. After biopsy we came to know that she has been suffering from "ALPORT'S SYNDROM" confirmed by "NATIONAL UNIVERSITY HOSPITAL" Singapore by "Professor Yap Hui Kim". Please do help us by latest information. Thanking you Sk Mogfur Ahmed Bangladesh YYYY@YYYY
Thu, 19 Mar 2015
hello Mr. Sk Mogfur Ahmed .
Extremely sorry to know about your grand child's condition.
To practically speak about Alport's syndrome, it is a genetic disorder caused due to mutations in genes related to collagen synthesis. It can mainly cause renal problems and also associated cataracts and hearing loss.
as such this disease does not have definitive cure but progression of the disease to end stage renal disease can be delayed by using:
1. Antihypertensives like ACE inhibitors (controls hypertension and decreases proteinuria)
2. Vitamin D and phosphate binders to control osteodystrophy (Controls bone tissue loss)
3. Alkali to control metabolic acidosis.
4. if kidney failure occurs then doctors opt for dialysis and kidney transplant
but since the transplanted kidney has normal collagen synthesis , it may get rejected.
Of late gene therapy is coming up with better research on alports syndrome but sadly there is nothing substantial yet.
hope this helped . take care.
Dr.Riyanka
Extremely sorry to know about your grand child's condition.
To practically speak about Alport's syndrome, it is a genetic disorder caused due to mutations in genes related to collagen synthesis. It can mainly cause renal problems and also associated cataracts and hearing loss.
as such this disease does not have definitive cure but progression of the disease to end stage renal disease can be delayed by using:
1. Antihypertensives like ACE inhibitors (controls hypertension and decreases proteinuria)
2. Vitamin D and phosphate binders to control osteodystrophy (Controls bone tissue loss)
3. Alkali to control metabolic acidosis.
4. if kidney failure occurs then doctors opt for dialysis and kidney transplant
but since the transplanted kidney has normal collagen synthesis , it may get rejected.
Of late gene therapy is coming up with better research on alports syndrome but sadly there is nothing substantial yet.
hope this helped . take care.
Dr.Riyanka
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