Hi. H Pylori is not the sole cause of upper abdominal pain. As the nexium is not helping you, we should go for finding other causes of pain in upper abdomen and bloating. I would suggest in such a patient the following: Investigations: *Routine blood investigations like Complete blood picture, blood sugar, urea, creatinine, liver function tests, thyroid function tests. *Urine -routine and microscopy *Stool: routine, microscopy, occult blood, culture and sensitivity. *Ultrasonography of abdomen, *Colonoscopy All these investigations should be within normal limits for one to say you have IBS. Further treatment will be easy and fruitful if we find the correct reason of your symptoms.