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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Suggest Treatment For RA Despite Taking Prednisone And Methotrexate

I am currently taking Prednisone, generic form of Plaquenil, and Methotrexate for my R.A. I m having difficulty remaining asleep through the night, lots of tossing and turning and my brain in constant overdrive! My chiropractor suggested taking Melatonin a half hour before actually going to sleep. Is taking Melatonin safe with my current medications?
Wed, 16 Mar 2016
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General & Family Physician 's  Response
HI, thanks for using healthcare magic

There are no interactions between melatonin and the other medications but there is a risk of interaction between the plaquenil and methotrexate.
This means that the melatonin can be safely added.

Plaquenil decreases the level of methotrexate by an unknown mechanism.

I hope this helps

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Suggest Treatment For RA Despite Taking Prednisone And Methotrexate

HI, thanks for using healthcare magic There are no interactions between melatonin and the other medications but there is a risk of interaction between the plaquenil and methotrexate. This means that the melatonin can be safely added. Plaquenil decreases the level of methotrexate by an unknown mechanism. I hope this helps