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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Suggest Treatment For Mansonella Perstans Infection

Do you know how to diagnose and treat mansonella pertans? This is a neglected tropical disease that came from south or central America. Related forms also come from Africa. Mansonella ozzardi may be a co-infection. The combination of Ivermectin, albendazole and diethylcarbamazine in combination seem to be the most effective treatment in terms of reducing or eliminating the microfilaria in the blood, and possibly killing the adult worms that may occupy the serous cavities. The patient has had this for some time and has been ignored by doctors because these parasites are not common in North America. Her condition is worsening and it seems that trying to treat it has less risk than the pain and other symptoms that are acute at times. The WHO administers these drugs in widespread mass drug administration programs through community centers and aid workers, so access should be possible anywhere. What are your thoughts or suggestions?
Thu, 27 Apr 2017
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General & Family Physician,  's  Response
Mansonella Perstans infestation can be diagnosed by-
-Complete physical examination that reveal typical rash and edematous swelling of affected body parts
-A careful travel history to the known endemic parts mentioned by you.
-Blood examination may reveal larvae of Mansonella Perstans under microscope
-Microscopic examination of exudative serous fluid from the affected parts, pleural effusions can also demonstrate larvae.

Treatment includes-
A combination of the drugs you mentioned above- Ivermectin, Albendazole and DEC together produce best results.
A follow up is required after starting the treatment with these drugs to find the effectiveness and any side effects of the treatment.
Though generally many patients are asymptomatic and are not even aware that they are infected. Even the symptomatic patients don't have any major complaints other than mild fever, occasional rash and swelling, headache.

Hope this helps, thank you.
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Suggest Treatment For Mansonella Perstans Infection

Mansonella Perstans infestation can be diagnosed by- -Complete physical examination that reveal typical rash and edematous swelling of affected body parts -A careful travel history to the known endemic parts mentioned by you. -Blood examination may reveal larvae of Mansonella Perstans under microscope -Microscopic examination of exudative serous fluid from the affected parts, pleural effusions can also demonstrate larvae. Treatment includes- A combination of the drugs you mentioned above- Ivermectin, Albendazole and DEC together produce best results. A follow up is required after starting the treatment with these drugs to find the effectiveness and any side effects of the treatment. Though generally many patients are asymptomatic and are not even aware that they are infected. Even the symptomatic patients don t have any major complaints other than mild fever, occasional rash and swelling, headache. Hope this helps, thank you.