I seem to be very resistant to painkillers, my latest is tramadol, I ve been on it for 3 days and for sure can feel it s side effects but as per usual it s not helped the pain. I got given two weeks work but my doctor said by 3 days I should know of it will help with the pain or not. It s not touched the pain. What would the next painkiller to try? I ve been on cocodamol, codydramol, amytriptaline, naproxen, zapain and tramadol. I am worried about going on more opiates since I go back to University I m September need tone able to cognitively function but also be in as little pain as possible. Thank you.