my mother is 56 year old , had diagnosed 12 yrs of DM, on metformin 850 mg BD, she diagnosed HTN since 10 years, on Amlodipine 5 ng, losarton 50 mg, atenolol 25 mg and lorvas 2.5 mg. she found her sr critinine 4.7 mg/dl without moch symptom, what do u advice?