Thanks for your health concerns. I agree that if you see a big difference in terms of your fatigue
after starting pendolol, it is a possibility to consider that the medication could actually be contributing to the fatigue. This is a well described side effect for B Blockers. Discontinuing a beta blocker
abruptly indeed carries risks of rebound side effects, so the medication has to be weaned off gradually or substituted by another type of B blocker. My suggestion in patients with your symptoms would typically be atenolol
, which does not act on the nervous system.
Dr Brenes-Salazar MD
Mayo Clinic MN