Dear i can understand you concern i my opinion the changes done by your doctor are not very pleasing. Daonil is also called as glibenclamide. this medication is associated with high rate of severe hypoglycemia and its not good for your heart. each time you suffer a hypoglycemia there will a chance of cardiac arrhythmia and brain damage. most of our brain depends only on glucose for its daily activities. due to excessive use of daonil your pancreas might go into secondary failure soon. There are many other medications like amaryl and diamicron mr and minidiab which are having better cardiometabolic profile. i suggest to discuss with your doc regarding change of medication. Regards