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Prescribed Macox for uterus infection. Should the entire course of medicine be taken?

My daughter now aged 13 yrs weight 46 kg, primarily diagnosed in an ultrasound ,that she has an infection (wetness) in uterus . After further checking of her menstrual blood for TB-PCR a bacteria was detected “ Mycobacterium Tuberculosis Complex”. After that I consulted a medical college professor who is a TB specialist. He started a tablet R-CINEX Z ( Rifampicin -225mg + Isoniazid -150mg + Pyrazinamide -750mg)1.5 tab daily for 11/2 month from 17-04-2012. After that he increased the dose to 2tab daily for 15 days. Further ,he changed the medicine and started a new medicine named Macox Plus (Rifampicin- 450 mg and Isoniazid -300mg) one tab daily. On my last visit he told me that after a course of 51/2 months , stop the medicine. So he has given the complete course for 71/2 months .He hasn’t advised me for any further diagnosis. But my family physician advised me to complete the course for total 9 months. It means Macox plus is to be given for 7 months. He also advised me for a new ultrasound scan for uterus. So ,there is a very big confusion please advise me. Now she is taking one tab of Macox Plus daily in the morning
Asked On : Tue, 27 Nov 2012
Answers:  1 Views:  93
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Pathologist and Microbiologist 's  Response
Hello and welcome to HCM
Tuberculosis is an infectioud disease caused by a bacteria called Mycobacterium tuberculosis. Lungs are the most common site of the infection. However, any organ of the body can be involved like brain, skin, bone kidney, uterus so on and so forth.
The infection is treated by a combination of drugs- rifampicin, isoniazid, pyrazinamide and ethanbutol.
People who do not respond or develop adverse effects to these first line drugs are given second line drugs.
It is important to continue the drugs for the prescribed period without missing any dose.
Supplements have to be taken- Vitamin B 6, multivitamins and liver protective capsules. Two of these drugs are excreted by the liver so liver protective capsules are a must.
The duration of the treatment varies with site of the infection.
The treatment duration varies from 6 months to one and a half years. Specialist in this field ie Pulmonary medicine/ TB & Chest are well versed in this field.
There is a regular updating of duration of treatment.
So, I would suggest you to stick to the regime suggested by your pulmonologist.
Investigations should/ will be repreated at the end of the treatment period to rule out residual infection or a relapse.

Thanks and take care
Dr Shailja P Wahal

Answered: Tue, 27 Nov 2012
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