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Velcade contains Bortezomib.
It is proteosome inhibitor.
In normal cells, the proteasome regulates protein expression and function by degradation of ubiquitylated proteins
, and also cleanses the cell of abnormal or misfolded proteins.
cells, Bortezomib proteasome inhibition may prevent degradation of pro-apoptotic factors, permitting activation of programmed cell death in neoplastic cells dependent upon suppression of pro-apoptotic pathways.
is a nitrogen mustard alkylating agent.
The main effect of cyclophosphamide
is due to its metabolite phosphoramide mustard. This metabolite is only formed in cells that have low levels of ALDH.
Phosphoramide mustard forms DNA crosslinks both between and within DNA strands at guanine N-7 positions (known as interstrand and intrastrand crosslinkages, respectively). This is irreversible and leads to cell death.
Entecavir is a Barculade.
Entecavir is a oral antiviral
drug used in the treatment of hepatitis B
Hope this helps. Please reply for further queries.
Wishing you good health.