Hi there , thanks for posting your query at Healthcare Magic Loosing weight intentionally or due to some diseases like diabetes , hypothyroidism and heart ailments can put the call into lots of trouble . The entire metabolism of the cell is disrupted , cell looses it elasticity and results ion itch When we loose weight sometime the liver dysfunction can also result which is a major cause of itch. It is better to seek a medical advice. Take good amount liquid diet, apply good moisturizing cream or lotions Ask the physician if he advices you to go for certain liver function tests . And consult him before taking any antihistamines. Take care