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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is There Something To Worry If Globulin Is Level 4.8?

in my liver funciton test i got globulin level 4.8 ( ref values given are 2.5-3.5) and my A/G Ratio is 0.7 ( ref is 1.0-2.1). the doctor told liver is normal. i want to know that if less a/g ratio is there any liver disease is present in my body. please suggest me.

thanks
ramesh
Thu, 17 Mar 2016
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General & Family Physician,  's  Response
Hi thanks for asking question.

The albumin produce from liver.So if liver disease is present then albumin low and compensatory globulin elevated so a/g ratio less.So rule out cirrhosis or other liver problem by USG and viral markers.

If excess excretion of albumin occur in urine then also albumin decreased like in nephritic syndrome ...Do urine albumin and RFT for that.

Sometimes protein loosing enteropathy can lead hypoalbuminemia.So rule out gastrointestinal disorders.

Thyrotoxicosis, prolonged chronic infections, prolong fever can lead to hypoalbumin.

So yes liver problem can lead low albumin .first rule out it then if liver normal rule out other condition.


Take care
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Is There Something To Worry If Globulin Is Level 4.8?

Hi thanks for asking question. The albumin produce from liver.So if liver disease is present then albumin low and compensatory globulin elevated so a/g ratio less.So rule out cirrhosis or other liver problem by USG and viral markers. If excess excretion of albumin occur in urine then also albumin decreased like in nephritic syndrome ...Do urine albumin and RFT for that. Sometimes protein loosing enteropathy can lead hypoalbuminemia.So rule out gastrointestinal disorders. Thyrotoxicosis, prolonged chronic infections, prolong fever can lead to hypoalbumin. So yes liver problem can lead low albumin .first rule out it then if liver normal rule out other condition. Take care