Hello, Hypertriglyceridemia or excess triglycerides in body is treated first by lifestyle modification like cessation of smoking and alcohol, daily physical exercise for 45 min/day at least 5 days a week, avoidance of fatty foods, having foods rich in fiber like fruits, nuts, oats etc., cutting down the carbohydrates and weight reduction which helps a lot in decrease in triglycerides. Pharmacological therapy or medicines are indicated when the LDL cholesterol levels are as follows: * Patients with low risk, 190 mg/dL or greater * Patients with moderate risk, 160 mg/dL or greater * Patients with moderately high risk, 130 mg/dL (option 100 mg/dL) or greater * Patients with high risk, 100 mg/dL (option 70 mg/dL) or greater Because of the possibility of adverse effects, many physicians use drugs to reduce the triglyceride level only when the level exceeds 500 mg/dL. Patients with triglyceride concentrations greater than 1000 mg/dL should receive diet and drug therapy and be closely monitored to prevent pancreatitis. Drugs used to treat hypertriglyceridemia are Fibric acid derivatives, Omega 3 fatty acids, Niacin and statins in high doses. So, you can use Rosuvastatin 40 mg and it can help in reducing triglycerides up to 50%. You can also use Niacin and Omega 3 fatty acids if your uncle can t tolerate fenofibrate. Take care. Hope I have answered your question. Let me know if I can assist you further. Regards, Dr. Pallavi M., Anesthesiologist