The first thing in such creams is to perform patch test
as the chemicals can cause allergy
to any one. If in patch test there is no irritation then it can be applied. As far as damage to the scrotal region is concerned , there is no data available as to contra indications yet. It is quite safe for pubic hair, there is no mention of adverse effect on sex or testicles. so hope fully the mannual of the cream being used mentions no contraindications.