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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Is A Bone Marrow Replacement Necessary In ALLB?

my kid was detected with ALLB in nov 2009.He completed his chemotherapy 6 cycles and was in maintainence phase.15 days before he had a severe head ache.doc asked for CSF test.Test showed 200 blasts in CSF.he has a relapse in CNS after 18 months.he is now 5.5 yrs. doc says he needs a chemo again consisting of 6 cycles including 2-3 additional drugs which were not used before & radiation therapy in last cycle.i want to confirm if the diagnosis & prognosis are going fine? what is thw reason for relapse? what are the chances of cure after treatment.His bone marrow at present is intact, can he need a transplant,how useful can it be? are there chances of relapse even after transplant? he does not have brother or sister? what are the chances of getting a right match & cost ?can alternative medicines like homeo or ayurveda used as supportive medicines during chemo?How fatal can a relapse in CNS be?can he be cured completely?

Thaking you & awaiting for reply,

swati.
Mon, 23 Mar 2015
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Pediatrician, Hematology Oncology,  's  Response
relape of ALL can be cured in about 60-70%kids. we have to check whether it is isolated brain fluid relapse or bone marrow is also involved. he definatrly need chemotherapy and cranial radiation. role of BMT in isolated brain relapse is doubtful. if bone marrow is also showing relapse, i would like to do allogeneic BMT after these therapy. even if no sibling is present , an matched unrelated BMT can be done [registries charges for processing about 9 lakhs in India and Germany; 25 lakhs from US]. a half match transplant will be considered as well [no additional cost, mother or father being donor]. discuss with your oncologist, he will guide you.
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Is A Bone Marrow Replacement Necessary In ALLB?

relape of ALL can be cured in about 60-70%kids. we have to check whether it is isolated brain fluid relapse or bone marrow is also involved. he definatrly need chemotherapy and cranial radiation. role of BMT in isolated brain relapse is doubtful. if bone marrow is also showing relapse, i would like to do allogeneic BMT after these therapy. even if no sibling is present , an matched unrelated BMT can be done [registries charges for processing about 9 lakhs in India and Germany; 25 lakhs from US]. a half match transplant will be considered as well [no additional cost, mother or father being donor]. discuss with your oncologist, he will guide you.