It sounds like you are having a tough time. As a cardiologist, I often see people who have chest pains that we cannot explain. Admittedly we believe in a large proportion of these cases that it is due to anxiety. Anxiety and panic attacks can definately cause chest pain (just think of that horrible feeling you get when someone startles you!). What you should try to be reassured by is the negative tests you have had. Whilst we are sometimes not able to exactly explain WHY you have your symptoms, we are very very good at excluding the serious causes....like coronary artery disease. You can be really reassured that if you cardiologist is happy with your tests that it is very very unlikely that you have significant (or any) coronary artery disease. We sometimes quote prognostic statistics related to a negative test....roughly, if you have a negative stress test then your chance of having a heart attack in the next year is less than 0.1% (which is pretty damn low). So what can you do to help yourself? Well the first, and most important thing, is that you should keep active and make sure you are protecting yourself from ever developing cardiac problems. So if that means modifying your lifestyle, stopping smoking, getting more exercise then that is certainly going to protect you from ever having significant problems in the future. If your cardiologist thinks your pain sounds like angina (or you have good relief of pain with your GTN/NTG spray) then sometimes, even with negative tests, they might consider a trial of anti-angina drugs. In a tiny proportion of cases the pain can be caused by coronary artery spasm or even simply chest wall or oesophageal spasm. But the most important thing by far is that with a negative stress test you are in a great prognostic group (basically have the same background risk as any other healthy person). So you can be reassured. I agree, that if you feel anxiety is a clear precipitant then it might be worthwhile considering treatment. I wouldnt go plowing in with drugs. I think that the best policy is to try and learn coping strategies for the anxiety.....that might be from counselling or CBT (cognitive behavioural therapy). Your GP can arrange psychological referral if indicated, and many practices have relaxation classes or counsellors on hand to try......worth a shot. Hope things settle down for you....I know it can be a real pain (yeah, bad pun). Just remember that you are in a low risk group, and you should do everything you can to stay that way (keep fit, watch you diet etc etc etc). That is the best policy for all of us.....best of luck!