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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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How To Treat Over Secretion Of Gastrin/ Hormone Levels,enlarged Spleen And Swollen Stomach Inner Lining While On Nexium?

I am a 26 year old female. Started in March 2013 admitted to hospital, very sick threw up blood. Got blood transfusion, iron infusion and a whole range of tests over a 1 week period. Since then I have had: -2x Iron infusions- seems to be stable for now -2x endoscopy’s -Endoscopy with ultrasound (Jan 2014) -Colonoscopy -MRI scan -Upper abdomen ultrasound, 2nd one will be later in Jan 2014. -Chest Xray -Numerous blood tests testing for, deficiencies, allergies, levels, helibacteria (which I don’t have apparently any of these) Things that the tests brought up were: -Enlarged spleen -Pancreas is producing over double the amount of gastrin/ hormone levels - Still since March 2013 to my latest internal endoscopy ultra sound Jan 2014 my stomach insides are inflamed and swollen! I have been on Nexium 40’s for the last aprox 9-10months…this masks the upper abdomen pain but I have continuous discomfort and nausea feeling every day. Can anyone suggest anything to help me?
Tue, 4 Feb 2014
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Addiction Medicine Specialist,  's  Response
Hi,

Since just Nexium is not providing adequate relief and the stomach is still inflamed, you are likely to benefit from taking over the counter antacids as well. Although Nexium can significantly reduce the acid production from the stomach, in your case, it appears the excess levels of gastrin from the pancreas is causing excessive gastric acid secretion which Nexium is unable to completely neutralize. Your doctors are looking for the cause for this excessive secretion of gastrin, but I do not know if they have found any gastrin secreting tumours that may be responsible. Octreotide can help reduce gastrin secretion. Please discuss with your doctors what their views are about using octreotide in your case.

Best wishes.
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How To Treat Over Secretion Of Gastrin/ Hormone Levels,enlarged Spleen And Swollen Stomach Inner Lining While On Nexium?

Hi, Since just Nexium is not providing adequate relief and the stomach is still inflamed, you are likely to benefit from taking over the counter antacids as well. Although Nexium can significantly reduce the acid production from the stomach, in your case, it appears the excess levels of gastrin from the pancreas is causing excessive gastric acid secretion which Nexium is unable to completely neutralize. Your doctors are looking for the cause for this excessive secretion of gastrin, but I do not know if they have found any gastrin secreting tumours that may be responsible. Octreotide can help reduce gastrin secretion. Please discuss with your doctors what their views are about using octreotide in your case. Best wishes.