I am on Pur-bloka as well as Wellbutrin, Quetiapine, Yaz, Dormonoct and Activan. I switched to Quietiapine from lithium last July and it has caused me to gain alot of weight (20kgs) - this has subsequently caused me to have tremors, high temperature, hot flushes and feeling fatigue. My doctor prescribed Pur-bloka for this. But can the Pur-Bloka be attributing to my weight gain? I am still gaining weight and it has become quite concerning as I have exercised and tried a balance diet and have not lost weight. What can I do to loose weight? Can I stop the Pur-bloka or decrease the dosage of Quetiapine? I have restricted calories, exercised, tried drinking more water. None has avail. Please help. The extra weight gain has severely limited my lifestyle.