E-mail: YYYY@gmail,com I am a nurse with varicose and spider veins and I get edema in ankles and lower legs from sitting or standing for prolonged periods. Edema goes away when lie down. Compression hose help some, but not with long hours. I take Rx meds: Low dose aspirin; pantoprazole; plavix; losartan; carvedilol; lipitor; metformin; glipizide Hx of: mild MI (stent placement main artery for blockage) heart function fine now , Stage 1 CVA (stent Left carotid), hypertenion, Type II diabetes. Meds, exercise, and diet changes all working fine and keeping labs and functions within normal limits. I have talked to several people that take CIRCULATION AND VEIN SUPPORT from Andrew Lessman s vitamin/mineral formulas and they say it really helps with edema and soreness. I can t find any interactions with any of Rx s I take, but most interaction checklists do not have everything listed and my regular MD s say are not sure because they don t know enough about herbs and supplements. The dosage is 2 capsules daily with following amounts per serving: Vitamin C 30mg; Diosmin 600mg; Hesperidin 100mg; Rutin 20mg; Grape Seed extract 40mg; Pine Bark 40mg; Butcher s Broom 40mg. Are there any ingredients in this supplement that would be contraindicated with my Rx meds or because I had a mild MI, ischemic stroke, or have stents. Thank You Beverly Blanton