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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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How Can Bilateral Renal Parenchymal Disease Be Treated For Resuming Chemotherapy?

Hi my mum has been undergoing chemotherapy and after the third course she developed high cretenine levels and as at last week the levels were 197umol.the oncologist referred us for an abdominal and pelvic u/s which was done today and it reveled that she had bilateral renal parenchymal disease.so which is the best way to teat the condition so that she can resume chemo?thanks
Mon, 8 Dec 2014
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Pulmonologist,  's  Response
Thanks for your question on HCM.
Many chemotherapy drugs are toxic on kidneys and actually damage them.
Ultrasound finding of renal parenchymal disease suggest renal toxicity only.
The first and foremost step is to stop chemotherapy. Drink plenty of fluids.
Low dose diuretic is given to stimulate urine.
Avoid fruits and fruit juices. Avoid over the counter pain killers as they are nephrotoxic too.
Repeat creatinine every 3rd day to see for decreasing trend.
And start new chemotherapy agent after normalisation of creatinine, which is not nephrotoxic.
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How Can Bilateral Renal Parenchymal Disease Be Treated For Resuming Chemotherapy?

Thanks for your question on HCM. Many chemotherapy drugs are toxic on kidneys and actually damage them. Ultrasound finding of renal parenchymal disease suggest renal toxicity only. The first and foremost step is to stop chemotherapy. Drink plenty of fluids. Low dose diuretic is given to stimulate urine. Avoid fruits and fruit juices. Avoid over the counter pain killers as they are nephrotoxic too. Repeat creatinine every 3rd day to see for decreasing trend. And start new chemotherapy agent after normalisation of creatinine, which is not nephrotoxic.