Thank you for your question. At this stage the most important diagnosis to rule out is a blood clot in the deep veins of the leg. In the absence of fever
of the lower leg, cellulitis
would be less likely. The fact that an ultrasound
was negative previously does not rule out this diagnosis. Also, the fact that you are being treated with estrogens increases your risk for clots. if you were my patient I would start by sending you to have an urgent repeat ultrasound by an expert sonographer.