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Dr. Andrew Rynne
MD
Dr. Andrew Rynne

Family Physician

Exp 50 years

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Have Radical Nephrectomy Of Left Kidney, Cholesterol Level Rising Often. Reason?

I have a radical nephrectomy of my left kidney on 31/7/13 my cholesterol at the time was 4.8 and was on Atorvastatin which was withheld because of my illness . Recent testing shows cholesterol now at 9 my GP has said not to worry. I had a Heart Attack in 2012 and 2 stents fitted. Why would cholesterol rise so quickly as so high as I can assure you that I have not been overeating and have actually lost 1.5 stones. Thank you.
Tue, 8 Oct 2013
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General & Family Physician 's  Response
hello there
i saw your query. lipids increase in renal disorders even when you dont take it. its because renal filtration mechanisms are disturbed. Lipid profile deranges in nephrotic range proteinurias( that is proteins in urine more than a gram a day) albumins in the body decrease and albumin to the globulin ratios are reversed. so this in turn is tried to be compensated by liver. and these low density lipoproteins and cholestrols are managed by your liver so lipids start rising in their levels..
so all you need is to control your kidneys profile. if you are hypertensive or just even renal patient with nephrotic range proteinuria, time to change dietary habits.. reduce salt intake to the minimum possible less than a gram a day. You should start ACE inhibitors as they are renal friendly..

the problem is your kidney and its the kidney leading to your secondary troubles like increased cholestrols, you did not mention but pulmonary involvement (lungs) and heart attack and gneralised swelling or simple swelling of the ankles all are attributed to your renal disturbance,,

so have a renal function tests,

get 24 hours urinary proteins,

serum albumins, A/G ratios,

u/s abdomen and pelvis,

flourescent studies of your GBM ( renal base structures)

and it will be better understood what to be done...

i wish you best of luck
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Have Radical Nephrectomy Of Left Kidney, Cholesterol Level Rising Often. Reason?

hello there i saw your query. lipids increase in renal disorders even when you dont take it. its because renal filtration mechanisms are disturbed. Lipid profile deranges in nephrotic range proteinurias( that is proteins in urine more than a gram a day) albumins in the body decrease and albumin to the globulin ratios are reversed. so this in turn is tried to be compensated by liver. and these low density lipoproteins and cholestrols are managed by your liver so lipids start rising in their levels.. so all you need is to control your kidneys profile. if you are hypertensive or just even renal patient with nephrotic range proteinuria, time to change dietary habits.. reduce salt intake to the minimum possible less than a gram a day. You should start ACE inhibitors as they are renal friendly.. the problem is your kidney and its the kidney leading to your secondary troubles like increased cholestrols, you did not mention but pulmonary involvement (lungs) and heart attack and gneralised swelling or simple swelling of the ankles all are attributed to your renal disturbance,, so have a renal function tests, get 24 hours urinary proteins, serum albumins, A/G ratios, u/s abdomen and pelvis, flourescent studies of your GBM ( renal base structures) and it will be better understood what to be done... i wish you best of luck